Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. Myopericytoma arises most commonly in the dermis or subcutaneous tissue of the extremities in adults.
Myopericytoma (MPC) is a recently proposed term to describe a group of tumours that originate from perivascular myoid cells and show a range of histological growth patterns. Only a small number of series describing MPC have been reported. MPC is frequently misdiagnosed as a sarcoma.
Synopsis
painful slowly growing nodule
concentric perivascular arrangement of plump spindle shaped cells
concentric pattern around blood vessels
myoid-appearing spindle cells
accentuation the vessel walls
fascicles of spindle cells, embedded in a myxoid stroma, bulged into the lumina of lesional vessels, reminiscent of myofibroma/myofibromatosis
Variants
intravascular myopericytoma (12358814)
Immunochemistry
tumoral spindle cells positive for
Diiferential diagnosis
infantile myofibroma (infantile myofibromatosis)
infantile hemangipericytoma
liposarcomas
monophasic synovial sarcoma
angiomatoid MFH
fibroma
perineurioma
leiomyoma
leiomyosarcoma
giant cell tumor of tendon sheath
reparative giant cell granuloma
angioleiomyoma
glomus tumor
hemangiomas
arteriovenous malformation (AVM)
| Features | MPC | IMF |
| HPC-like vascular space | ++ | + |
| concentric perivascular proliferation | +++ | + |
| zonation/biphasic appearance | + | +++ |
| glomus-like cells | + to +++ | - |
| hyalinized paucicellular areas | + | +++ |
| myoid-like cells | + | ++ |
| primitive cells | + | ++ |
| intravascular bulging | + | ++ |
| intravascular proliferation | + | ++ |
| myoid nodules | +/- | ++ |
| tumoral necrosis | - | + |
From Dray et al., 2006 (16394283)
See also
References
Wilson T, Hellquist HB, Ray S, Pickles J. Intranasal myopericytoma. A tumour with perivascular myoid differentiation: the changing nomenclature for haemangiopericytoma. J Laryngol Otol. 2007 Aug;121(8):786-9. PMID: 17419897
Dray MS, McCarthy SW, Palmer AA, Bonar SF, Stalley PD, Marjoniemi V, Millar E, Scolyer RA. Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol. 2006 Jan;59(1):67-73. PMID: 16394283
Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006 Jan;48(1):63-74. PMID: 16359538
Mentzel T, Tos AP, Sapi Z, Kutzner H. Myopericytoma of Skin and Soft Tissues: Clinicopathologic and Immunohistochemical Study of 54 Cases. Am J Surg Pathol. 2006 Jan;30(1):104-113. PMID: 16330949
McMenamin ME, Calonje E. Intravascular myopericytoma. J Cutan Pathol. 2002 Oct;29(9):557-61. PMID: 12358814