liposarcomas

Digital cases

 UI:322 : Metastatic liposarcoma (NOS)
 UI:477 - Retroperitoneal liposarcoma (NOS)
 JRC:14054 : lung metastasis of a liposarcoma of soft tissue.

Definition: Liposarcomas typically occur in middle aged to older adults, but also in young patients (19194281)

Conventional myxoid liposarcoma is by far the most common subtype of liposarcoma in young patients, with an excellent prognosis.

Two apparently novel subtypes of liposarcoma, termed pleomorphic myxoid liposarcoma and spindle cell myxoid liposarcoma comprise considerable percentages of liposarcomas in this age group and should be distinguished from conventional myxoid liposarcoma and conventional pleomorphic liposarcoma.

Pleomorphic myxoid liposarcoma and spindle cell myxoid liposarcoma most likely represent high-grade and low-grade variants of myxoid liposarcoma, respectively. Additional study of such cases will be necessary for definitive classification.

Classification

 well-differentiated liposarcoma and atypical lipomatous tumor
 myxoid liposarcoma
 dedifferentiated liposarcoma

References

 Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM, Folpe AL. Am J Surg Pathol. 2009 May;33(5):645-58. PMID: 19194281