Synopsis
2%-7% of non-Hodgkin lymphomas
Immunochemistry
CD30+
EMA+ (50%)
P53+
Variants
monomorphic ALCL
small cell ALCL
lymphohistiocytic ALCL
Hodgkin-like ALCL
sarcomatoid ALCL
neutrophil-rich ALCL
eosinophil-rich ALCL
signet-ring ALCL
Associations
HIV infection
Differential diagnosis
classic Hodgkin lymphoma
- syncitial variant of sclerosing nodular Hodgkin lymphoma
- lymphocyte depletion Hodkgkin lymphoma
sinusoidal CD30-positive large B-cell lymphoma (10757332)
HHV-8-associated lymphoma (15105661)
Carcinomas
melanoma
Molecular biology
fusion genes invoving the ALK gene
- NPM1/ALK fusion protein (70-80%) by t(2;5)(p23;q35)
- TPM3/ALK fusion protein (20%) by t(1;2)(q25;p23)
- MSN/ALK fusion protein by t(X;22)(q11;p23)
- ATIC/ALK fusion protein by inv(2)(p23q35)
- TFG/ALK fusion protein by t(2;3)(p23;q21)
- CLTC/ALK fusion protein by t(2;17)(p23;q23)
- ALO17/ALK fusion protein by t(2;17)(p23;q25)
- MYH9/ALK fusion protein t(2;22)(p23;q11.2)
See also
cutaneous CD30+ anaplastic large-cell lymphoma (cutaneous CD30+ ALCL)
References
Vassallo J, Lamant L, Brugieres L, Gaillard F, Campo E, Brousset P, Delsol G. ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin’s lymphoma: report of 10 cases.Am J Surg Pathol. 2006 Feb;30(2):223-9. PMID: 16434897
Allory Y, Merabet Z, Copie-Bergman C, Lange F, Yiou R, Gaulard P. Sarcomatoid variant of anaplastic large cell lymphoma mimics ALK-1-positive inflammatory myofibroblastic tumor in bladder. Am J Surg Pathol. 2005 Jun;29(6):838-9; PMID: 15897755
Nakamura S, Shiota M, Nakagawa A, Yatabe Y, Kojima M, Motoori T, Suzuki R, Kagami Y, Ogura M, Morishima Y, Mizoguchi Y, Okamoto M, Seto M, Koshikawa T, Mori S, Suchi T. Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM/ALK) expression. Am J Surg Pathol. 1997 Dec;21(12):1420-32. PMID: 9414185