Synopsis
exudative phase of acute lung injury
- proliferative phase of acute lung injury
- edema
- inflammatory infiltrate
- pneumocyte hyperplasia
- fibrinous exudates
- organization
diffuse alveolar damage pattern of acute lung injury
acute fibrinous organizing pneumonia pattern (AFOP pattern)
squamous metaplasia
scattered multinucleate giant cells
vascular fibrin thrombi
pulmonary infarcts
vascular endothelial damage of both small- and mid-sized pulmonary vessels
Complications
invasive fungal disease
- Aspergillosis
cytomegalovirus infection
References
Stadler K, Rappuoli R. SARS: Understanding the Virus and Development of Rational Therapy. Curr Mol Med. 2005 Nov;5(7):677-97. PMID: 16305493
Hwang DM, Chamberlain DW, Poutanen SM, Low DE, Asa SL, Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol. 2005 Jan;18(1):1-10. PMID: 15272286
Peiris JS, Guan Y, Yuen KY. Severe acute respiratory syndrome. Nat Med. 2004 Dec;10(12 Suppl):S88-97. PMID: 15577937
Peiris JS, Yuen KY, Osterhaus AD, Stohr K. The severe acute respiratory syndrome. N Engl J Med. 2003 Dec 18;349(25):2431-41. PMID: 14681510
Drosten C, Preiser W, Gunther S, Schmitz H, Doerr HW. Severe acute respiratory syndrome: identification of the etiological agent. Trends Mol Med. 2003 Aug;9(8):325-7. PMID: 12928032
Chan HL, Tsui SK, Sung JJ. Coronavirus in severe acute respiratory syndrome (SARS). Trends Mol Med. 2003 Aug;9(8):323-5. PMID: 12928031