Congenital hemangiomas
RICH and NICH had many similarities, such as appearance, location, size, and sex distribution. The obvious differences in behavior served to differentiate RICH, NICH, and common GLUT1+ infantile hemangioma.
Magnetic resonance imaging (MRI) of the three tumors is quite similar, but some RICH also had areas of inhomogeneity and larger flow voids on MRI and arterial aneurysms on angiography. The histologic appearance of RICH differed from NICH and common GLUT1+ infantile hemangioma, but some overlap was noted among the three lesions.
Synopsis
small-to-large lobules of capillaries
moderately plump endothelial cells and pericytes
lobules surrounded by abundant fibrous tissue.
central involuting zone(s) characterized by lobular loss, fibrous tissue, with large and abnormal draining channels (50%)
hemosiderin thrombosis
cyst formation
focal calcification
extramedullary hematopoiesis
Immunochemistry
With rare exceptions, endothelial cells in RICH (as in NICH) did not express glucose transporter-1 protein (GLUT1)
Variants
Associations
chorangioma (17937433)
infantile hemangioma (17937433)
See also
vascular tumors
-
congenital hemangioma
- NICH (non-involuting congenital hemangioma)
References
Mulliken JB, Bischoff J, Kozakewich HP. Multifocal rapidly involuting congenital hemangioma: A link to chorangioma. Am J Med Genet A. 2007 Oct 15; PMID: 17937433
Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE, Perez-Atayde AR, Kozakewich HP. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003 Nov-Dec;6(6):495-510. PMID: 15018449