Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression.
A single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation.
See also
chromatin-modifying proteins cooperate
References
Ooi L, Wood IC. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet. 2007 Jul;8(7):544-54. PMID: 17572692