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REST

Sunday 15 July 2007

Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression.

A single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation.

See also

- chromatin-modifying proteins cooperate

References

- Ooi L, Wood IC. Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet. 2007 Jul;8(7):544-54. PMID: 17572692