MTA1 is a metastasis-associated gene with histone deacetylase activity.
Pathology
MTA1 has been identified as a metastasis-promoting gene
- MTA1 gene expression is correlated with serosal invasion and lymph node metastasis in the gastrointestinal and esophageal cancers
- MT1A is overexpressed in pancreatic carcinomas (MT1A is involved in the progression, particularly in lymph node metastasis.)