Pathology
MECT1-MAML2 gene fusion by t(11;19)(q21;p13) in
- mucoepidermoid carcinoma
- benign Warthin tumor
- cutaneous clear cell hidradenoma (15729701)
References
Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin’s tumors: implications for histogenesis and biologic behavior. Genes Chromosomes Cancer. 2007 Jul;46(7):708-15. PMID: 17437281
Winnes M, Molne L, Suurkula M, Andren Y, Persson F, Enlund F, Stenman G. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer. 2007 Jun;46(6):559-63. PMID: 17334997
Tonon, G.; Modi, S.; Wu, L.; Kubo, A.; Coxon, A. B.; Komiya, T.; O’Neil, K.; Stover, K.; El-Naggar, A.; Griffin, J. D.; Kirsch, I. R.; Kaye, F. J. : t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nature Genet. 33: 208-213, 2003. PubMed ID : 12539049
Behboudi A, Enlund F, Winnes M, Andren Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Makitie A, Grenman R, Mark J, Stenman G. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer. 2006 May;45(5):470-81. PMID: 16444749