CD34
MIM.142230 1q32
CD34 is a monomeric cell surface sialomucin with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.
Function
At least three endothelial cell ligands can bind L-selectin:
glycan-bearing cell adhesion molecule-1 (GlyCAM-1), a secreted proteoglycan found on HEVs of lymph node
mucosal addressin cell adhesion molecule-1 (MadCAM-1), expressed on endothelial cells in gut-associated lymphoid tissues
CD34, a proteoglycan on endothelial cells (and bone marrow cells).
The protein backbones of all these ligands are modified by specific carbohydrates, which are the molecules actually recognized by the selectins (SELs).
Expression in normal cells
human hematopoietic progenitor cells
endothelial cells
adipocytes
Expression in tumors
lipomas
solitary fibrous tumors
dermatofibrosarcoma protuberans and giant cell fibroblastoma
+/- acute leukemias
nodular hairy dendritic hamartoma of the newborn
smooth muscle hamartoma