Synopsis
chronic inflammatory infiltrate (Grade 1)
lamina propria neutrophils and eosinophiles (Grade 2)
neutrophils in epithelium (Grade 3)
crypt destruction (Grade 4)
mucosal ulceration or ulceration (Grade 5)
colonic inflamatory pseupolyp
Associations
backwash ileitis
postcolectomy pouchitis
diffuse duodenitis (11023103)
Complications
colonic adenoma
dysplasia-associated lesion or mass (DALM)
ulcerative colitis-associated colorectal adenocarcinoma
Differential diagnosis
colonic Crohn disease
References
Tsang P, Rotterdam H. Biopsy diagnosis of colitis: possibilities and pitfalls.Am J Surg Pathol 1999 Apr;23(4):423-30
Kleer CG, Appelman HD. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time.Am J Surg Pathol 1998 Aug;22(8):983-9
Variants
steroid-refractory ulcerative colitis
- association with CMV infection (15104299)
Videos
Colonoscopy of ulcerative colitis
References
Sandle GI. Pathogenesis of diarrhea in ulcerative colitis: new views on an old problem. J Clin Gastroenterol. 2005 Apr;39(4 Suppl 2):S49-52. PMID: 15758659
Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002 Aug 8;347(6):417-29. PMID: 12167685
Price AB, Morson BC. Inflammatory bowel disease: the surgical pathology of Crohn’s disease and ulcerative colitis. Hum Pathol. 1975 Jan;6(1):7-29. PMID: 1089084