t(1;14)(p22;q32)
non Hodgkin Lymphomas (NHL)
- diffuse large B-cell lymphoma
- lymphoplasmacytic lymphoma
- some extranodal MALT lymphomas
- pulmonary extranodal marginal zone B-cell lymphoma
hairy cell leukemia
acute lymphoblastic leukemia/lymphoblastic lymphoma
B-prolymphocytic leukemia
Genes involved
IGH at 14q32
BCL10 at 1p22
- mutation or deletion of the BCL10 gene in 5-10% of
- extra-nodal MALT lymphomas (high-grade histology)
- follicle B-cell lymphoma
- diffuse large B-cell lymphoma
