Human pathology

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superficial fibromatoses

Types

- palmar fibromatosis (Dupuytren disease)
- plantar fibromatosis
- penile fibromatosis (Lapeyronie disease)

Cytogenetics

- near-diploid karyotypes with simple numerical changes

  • gain of chromosome 7 (trisomy 7)
  • gain of 8 (trisomy 8)

Differential diagnosis

- desmoid fibromatosis (deep fibromatosis, desmoid tumor, aggressive fibromatosis)

References

- Montgomery E, Lee JH, Abraham SC, Wu TT. Superficial fibromatoses are genetically distinct from deep fibromatoses. Mod Pathol. 2001 Jul;14(7):695-701. PMID: 11455002