Definition: Somatic mutation theory of cancer is a theory on the pathogenesis of cancer that essentially postulates that cancer in somatic cells arises from mutations. More recently, the theory has been adapted to specifically implicate mutations in oncogenes or tumour suppressor genes.
See also
oncogenesis/tumorigenesis
somatic mutations
DNA mutations/genic mutations
Reviews
Futreal PA. Backseat drivers take the wheel. Cancer Cell. 2007 Dec;12(6):493-4. PMID: 18068625
References
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O’Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR.Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. PMID: 17344846
Dalgliesh GL, Futreal PA. The continuing search for cancer-causing somatic mutations. Breast Cancer Res. 2007;9(1):101. PMID: 17319975
Futreal PA, Wooster R, Stratton MR. Somatic mutations in human cancer: insights from resequencing the protein kinase gene family. Cold Spring Harb Symp Quant Biol. 2005;70:43-9. PMID: 16869737
Greenman C, Wooster R, Futreal PA, Stratton MR, Easton DF.Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics. 2006 Aug;173(4):2187-98. PMID: 16783027
Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague J, Butler A, Edkins S, Stevens C, Parker A, O’Meara S, Avis T, Barthorpe S, Brackenbury L, Buck G, Clements J, Cole J, Dicks E, Edwards K, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Shepherd R, Small A, Solomon H, Stephens Y, Tofts C, Varian J, Webb A, West S, Widaa S, Yates A, Brasseur F, Cooper CS, Flanagan AM, Green A, Knowles M, Leung SY, Looijenga LH, Malkowicz B, Pierotti MA, Teh BT, Yuen ST, Lakhani SR, Easton DF, Weber BL, Goldstraw P, Nicholson AG, Wooster R, Stratton MR, Futreal PA. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res. 2005 Sep 1;65(17):7591-5. PMID: 16140923