pulmonary lesions in CVID
Definition: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and an inability to make specific antibodies. Common variable immunodeficiency (CVID) is a heterogeneous immunodeficiency that is accompanied by granulomatous lesions in 5-10% of cases.
Synopsis
nodules
bronchiectasis
air trapping
peribronchial nodules
infectious pulmonary complications
- encapsulated bacteria
- atypical bacteria
noninfectious diffuse lung diseases
- pulmonary lymphoid hyperplasia
- lymphoid interstitial pneumonia (LIP)
- follicular bronchiolitis (bronchial MALT lymphoma hyperplasia)
granulomatous-lymphocytic interstitial lung disease (GLILD) (15316526)
- noncaseating granulomas (15971440, 16954938)
- organizing pneumonia (16954938)
- lymphoid interstitial pneumonia (LIP)
Bates groups (15316526)
Bates group 1: no pulmonary disease
Bates group 2: chronic respiratory symptoms without diffuse radiographic abnormalities
Bates group 3: chronic respiratory symptoms and diffuse radiographic abnormalities.
- Bates subgroup 3A: granulomatous-lymphocytic interstitial lung disease (GLILD) (granulomatous lung disease, lymphocytic interstitial pneumonia, follicular bronchiolitis, and lymphoid hyperplasia)
- Bates subgroup 3B: all other types of interstitial lung disease (ILD)
References
Busse PJ, Farzan S, Cunningham-Rundles C. Pulmonary complications of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2007 Jan;98(1):1-8; PMID: 17225714
Tanaka N, Kim JS, Bates CA, Brown KK, Cool CD, Newell JD, Lynch DA. Lung diseases in patients with common variable immunodeficiency: chest radiographic, and computed tomographic findings. J Comput Assist Tomogr. 2006 Sep-Oct;30(5):828-38. PMID: 16954938
Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol. 2004 Aug;114(2):415-21. PMID: 15316526