NAIL INVOLVEMENT:
seen in up to 50% of psoriasis patients, more common in patients with psoriatic arthropathy
histopath -> psoriasiform onychitis with spongiform pustulation, negative fungal special stains (see photos)
differential -> onychomycosis, eczematous onychitis, Reiter syndrome
Susceptibility loci
PSORS1 locus at 6p21 (12148091)
IL12B variants (17236132)
IL23R variants (17236132)
Reviews
Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005 May 5;352(18):1899-912. PMID: 15872205
Gottlieb AB. Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov. 2005 Jan;4(1):19-34. PMID: 15688070
Bowcock AM, Cookson WO. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R43-55. PMID: 14996755
Bhalerao J, Bowcock AM. The genetics of psoriasis: a complex disorder of the skin and immune system. Hum Mol Genet. 1998;7(10):1537-45. PMID: 9735374
References
Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007 Feb;80(2):273-90. PMID: 17236132