Microscopical synopsis
intratumoral angiodysplasia
concentric cuffing of entrapped tubules ("onion skinning")
heterologous differentiation
epithelial components
- inactive embryonal epithelium (identical morphologically to metanephric adenoma (MA)
- carcinomatous component distinct from these lesions but identical morphologically to papillary renal cell carcinoma (PRCC).
Prognosis
metastases to the regional lymph nodes at the time of diagnosis (1/9) (11257617)
Differential diagnosis
congenital mesoblastic nephroma (CMN) -> intratumoral angiodysplasia, concentric cuffing of entrapped tubules ("onion skinning"), and heterologous differentiation. (11257617)
See also
References
Arroyo MR, Green DM, Perlman EJ, Beckwith JB, Argani P. The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol. 2001 Apr;25(4):433-44. PMID: 11257617