Human pathology

Home page > D. Systemic pathology > Hematologic disorders > leucocytic adhesion

leucocytic adhesion

leucocyte adhesion, leukocyte adhesion

Leukocyte adhesion and transmigration are regulated largely by the binding of complementary adhesion molecules on the leukocyte and endothelial surfaces, and chemical mediators-chemoattractants and certain cytokines-affect these processes by modulating the surface expression or avidity of such adhesion molecules.

The adhesion receptors involved belong to four molecular families:
- selectins (SELs)
- immunoglobulin superfamily (ICAMs)
- integrins (ITGs)
- mucin-like glycoproteins (like heparan sulfate).

References

- Rhee JS, Santoso S, Herrmann M, Bierhaus A, Kanse SM, May AE, Nawroth PP, Colman RW, Preissner KT, Chavakis T. New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products. Curr Mol Med. 2003 Jun;3(4):387-92. PMID: 12776993