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Home > E. Pathology by systems > Skin > generalized eruptive histiocytosis

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generalized eruptive histiocytosis

Generalized eruptive histiocytosis belongs to the cutaneous non-Langerhans cell histiocytoses and is a rare monocyte-macrophage proliferative disorder that usually follows a benign clinical course.

Synopsis

- erythematous macules and slightly elevated papules widely distributed over the trunk, neck, face, and thighs
- diffuse histiocytic infiltrate in the skin

Ultrastructurally

- no Birbeck granules

Immunochemistry

- S-100-
- CD1a-
- MS-1 high molecular weight protein + (highly characteristic for cutaneous non-Langerhans cell histiocytoses)

Associations

- acute monocytic leukemia (14576638)

Keywords