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acute monocytic leukemia

Sunday 21 November 2004

Digital case

- JRC:10576 : Monocytic leukemia

Cytogenetics

- t(9;22)(q34;q11) translocation (16518848)
- t(10;11)(p13;q14) translocation (16518848)

Gene overexpression

- HOXA9,

  • HOXA9 is essential to myeloid differentiation and is expressed in PICALM-MLLT10 and MLL-rearranged acute leukemias.

See also

- leukemias

References

- Sindt A, Deau B, Brahim W, Staal A, Visanica S, Villarese P, Rault JP, Macintyre E, Delabesse E. Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Genes Chromosomes Cancer. 2006 Jun;45(6):575-82. PMID: 16518848