focally enhanced gastritis
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Defeinition: Focally enhanced gastritis (FEG) is typified by small collections of lymphocytes and histiocytes surrounding a small group of foveolae or gastric glands, often with infiltrates of neutrophils.
Etiology (exemples)
IBDs
Synopsis
focal infiltration of CD3+ lymphocytes, CD68R+ histiocytes, and, in 80% of cases, of granulocytes
epithelioid granulomas
focally enhanced gastritis in 76% of H. pylori-negative patients with Crohn disease and in 0.8% of controls
Differential diagnosis
Helicobacter pylori-associated gastritis (33.3% of Crohn disease patients)
See also
- Crohn gastritis (Gastric Crohn disease)
References
Xin W, Greenson JK. The clinical significance of focally enhanced gastritis. Am J Surg Pathol. 2004 Oct;28(10):1347-51. PMID: 15371951
Furusu H, Murase K, Nishida Y, Isomoto H, Takeshima F, Mizuta Y, Hewlett BR, Riddell RH, Kohno S. Accumulation of mast cells and macrophages in focal active gastritis of patients with Crohn?s disease. Hepatogastroenterology. 2002 May-Jun;49(45):639-43. PMID: 12063959
Sharif F, McDermott M, Dillon M, Drumm B, Rowland M, Imrie C, Kelleher S, Harty S, Bourke B. Focally enhanced gastritis in children with Crohn?s disease and ulcerative colitis. Am J Gastroenterol. 2002 Jun;97(6):1415-20. PMID: 12094859
Oberhuber G, Puspok A, Oesterreicher C, Novacek G, Zauner C, Burghuber M, Vogelsang H, Potzi R, Stolte M, Wrba F. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn?s disease. Gastroenterology. 1997 Mar;112(3):698-706. PMID: 9041230