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focally enhanced gastritis

Monday 29 November 2004

Definition: Focally enhanced gastritis (FEG) is typified by small collections of lymphocytes and histiocytes surrounding a small group of foveolae or gastric glands, often with infiltrates of neutrophils.

Etiology (exemples)

- IBDs

  • Crohn gastritis
  • ulcerative colitis


- focal infiltration of CD3+ lymphocytes, CD68R+ histiocytes, and, in 80% of cases, of granulocytes
- epithelioid granulomas
- focally enhanced gastritis in 76% of H. pylori-negative patients with Crohn disease and in 0.8% of controls

Differential diagnosis

- Helicobacter pylori-associated gastritis (33.3% of Crohn disease patients)

See also

- Crohn disease

  • Crohn gastritis (Gastric Crohn disease)


- Focally enhanced gastritis in newly diagnosed pediatric inflammatory bowel disease. Ushiku T, Moran CJ, Lauwers GY. Am J Surg Pathol. 2013 Dec;37(12):1882-8. doi : 10.1097/PAS.0b013e31829f03ee PMID: 24121177

- The Clinical Significance of Focally Enhanced Gastritis in Children. McHugh JB, Gopal P, Greenson JK. Am J Surg Pathol. 2012 Oct 26. PMID: 23108022

- Xin W, Greenson JK. The clinical significance of focally enhanced gastritis. Am J Surg Pathol. 2004 Oct;28(10):1347-51. PMID: 15371951

- Furusu H, Murase K, Nishida Y, Isomoto H, Takeshima F, Mizuta Y, Hewlett BR, Riddell RH, Kohno S. Accumulation of mast cells and macrophages in focal active gastritis of patients with Crohn’s disease. Hepatogastroenterology. 2002 May-Jun;49(45):639-43. PMID: 12063959

- Sharif F, McDermott M, Dillon M, Drumm B, Rowland M, Imrie C, Kelleher S, Harty S, Bourke B. Focally enhanced gastritis in children with Crohn’s disease and ulcerative colitis. Am J Gastroenterol. 2002 Jun;97(6):1415-20. PMID: 12094859

- Oberhuber G, Puspok A, Oesterreicher C, Novacek G, Zauner C, Burghuber M, Vogelsang H, Potzi R, Stolte M, Wrba F. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease. Gastroenterology. 1997 Mar;112(3):698-706. PMID: 9041230