focally enhanced gastritis

Definition: Focally enhanced gastritis (FEG) is typified by small collections of lymphocytes and histiocytes surrounding a small group of foveolae or gastric glands, often with infiltrates of neutrophils.

Etiology (exemples)

 IBDs

• Crohn gastritis
• ulcerative colitis

Synopsis

 focal infiltration of CD3+ lymphocytes, CD68R+ histiocytes, and, in 80% of cases, of granulocytes
 epithelioid granulomas
 focally enhanced gastritis in 76% of H. pylori-negative patients with Crohn disease and in 0.8% of controls

Differential diagnosis

 Helicobacter pylori-associated gastritis (33.3% of Crohn disease patients)

See also

 Crohn disease

• Crohn gastritis (Gastric Crohn disease)

References

 Focally enhanced gastritis in newly diagnosed pediatric inflammatory bowel disease. Ushiku T, Moran CJ, Lauwers GY. Am J Surg Pathol. 2013 Dec;37(12):1882-8. doi : 10.1097/PAS.0b013e31829f03ee PMID: 24121177

 The Clinical Significance of Focally Enhanced Gastritis in Children. McHugh JB, Gopal P, Greenson JK. Am J Surg Pathol. 2012 Oct 26. PMID: 23108022

 Xin W, Greenson JK. The clinical significance of focally enhanced gastritis. Am J Surg Pathol. 2004 Oct;28(10):1347-51. PMID: 15371951

 Furusu H, Murase K, Nishida Y, Isomoto H, Takeshima F, Mizuta Y, Hewlett BR, Riddell RH, Kohno S. Accumulation of mast cells and macrophages in focal active gastritis of patients with Crohn’s disease. Hepatogastroenterology. 2002 May-Jun;49(45):639-43. PMID: 12063959

 Sharif F, McDermott M, Dillon M, Drumm B, Rowland M, Imrie C, Kelleher S, Harty S, Bourke B. Focally enhanced gastritis in children with Crohn’s disease and ulcerative colitis. Am J Gastroenterol. 2002 Jun;97(6):1415-20. PMID: 12094859

 Oberhuber G, Puspok A, Oesterreicher C, Novacek G, Zauner C, Burghuber M, Vogelsang H, Potzi R, Stolte M, Wrba F. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease. Gastroenterology. 1997 Mar;112(3):698-706. PMID: 9041230