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diabetes mellitus

Etiology

- type 1 diabetes
- type 2 diabetes (MIM.125853)

  • maturity-onset diabetes of the young (MODYs)
    • MODY1 (125850): mutation in the hepatocyte nuclear factor-4-alpha gene (HNF4A) on Ch.20 (MIM.600281)
    • MODY2 (MIM.125851): mutation in the glucokinase gene (GCK) (MIM.138079) on Ch.7

- autosomal dominant diabetes

  • rare activating ABCC8 mutations in autosomal dominant diabetes (12559865)

- pancreatic destruction

- neonatal diabetes mellitus

Lesions

- diabetic vasculopathy (diabetic vascular lesions)
- diabetic nephropathy
- diabetic retinopathy
- diabetic embryopathy

Videos

- Diabetes mellitus

- Type 2 Diabetes mellitus histopathology by Washington Deceit

See also

- Diabetes

References

- Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet. 2007 Sep;8(9):657-62. PMID: 17703236

- Camp HS, Ren D, Leff T. Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol Med. 2002 Sep;8(9):442-7. PMID: 12223316

- Langin D. Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J Med. 2001 Dec 13;345(24):1772-4. PMID: 11742055

Keywords