cyclosporine renal toxicity
Cyclosporine nephrotoxicity
Synopsis
normal kidney (cyclosporine can cause renal dysfunction by inducing vasoconstriction in the absence of morphological damage)
thrombotic microangiopathy (arterioles and glomerular tuft)
chronic glomerular injury
- segmental sclerosis superimposed on ischemic changes
- sharply delineated segmental sclerosis
- glomerular basement membrane corrugation
- glomerular basement membrane lamellation
- thickening of Bowman capsule
arteriolar hyalinosis (arteriolar hyalinization)
- concentric hyalin and medial vacuolization
- extension into the media
striped interstitial fibrosis
- fibrosis extending along medullary rays