Ciliated hepatic foregut cyst (CHFC) is a rare, benign, solitary cyst consisting of ciliated pseudostratified columnar epithelium, subepithelial connective tissue, a smooth muscle layer, and an outer fibrous capsule.
The epithelium lining ciliated hepatic foregut cysts has histological, histochemical, and immunohistochemical features similar to those observed in the bronchiolar epithelium. This lesion is a developmental ventral foregut abnormality that could arise from a bronchiolar bud of the tracheobronchial diverticulum. (10685641)
Synopsis
lining of the columnar epithelium composed of ciliated cells and mucin secreting goblet cells (10685641)
wall composed of bands of smooth-muscle fibers surrounded by an outer fibrous capsule (10685641)
Immunochemistry
endocrine cells within the cyst epithelium, positive for chromogranin, synaptophysin, bombesin, and calcitonin, and negative for serotonin, somatostatin, glucagon, insulin, gastrin, and pancreatic polypeptide (10685641)
References
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Chatelain D, Chailley-Heu B, Terris B, Molas G, Le Cae A, Vilgrain V, Belghiti J, Degott C, Flejou JF. The ciliated hepatic foregut cyst, an unusual bronchiolar foregut malformation: a histological, histochemical, and immunohistochemical study of 7 cases. Hum Pathol. 2000 Feb;31(2):241-6. PMID: 10685641
Vick DJ, Goodman ZD, Deavers MT, Cain J, Ishak KG. Ciliated hepatic foregut cyst: a study of six cases and review of the literature. Am J Surg Pathol. 1999 Jun;23(6):671-7. PMID: 10366149
Sato Y, Kitagawa S, Zen Y, Minato H, Nakanuma Y. Ciliated hepatic cyst without smooth muscle layer: A variant of ciliated hepatic foregut cyst? Pathol Int. 2006 Jun;56(6):340-4. PMID: 16704499
Vick DJ, Goodman ZD, Deavers MT, Cain J, Ishak KG. Ciliated hepatic foregut cyst: a study of six cases and review of the literature. Am J Surg Pathol. 1999 Jun;23(6):671-7. Review. PMID: 10366149
Terada T, Nakanuma Y, Kono N, Ueda K, Kadoya M, Matsui O. Ciliated hepatic foregut cyst. A mucus histochemical, immunohistochemical, and ultrastructural study in three cases in comparison with normal bronchi and intrahepatic bile ducts. Am J Surg Pathol. 1990 Apr;14(4):356-63. PMID: 2321699
Wheeler DA, Edmondson HA. Ciliated hepatic foregut cyst. Am J Surg Pathol. 1984 Jun;8(6):467-70. PMID: 6731667