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serotonin
Tuesday 4 May 2004
Serotonin is a preformed vasoactive amine with actions similar to those of histamine.
Serotonin is present in platelets, in enterochromaffin cells, and in mast cells (mastocytes) in rodents but not humans.
Release of serotonin, with histamine, from platelets is stimulated when platelets aggregate after contact with collagen, thrombin, adenosine diphosphate (ADP), and antigen-antibody complexes. Platelet aggregation and release are also stimulated by platelet activating factors (PAF) derived from mast cells during IgE-mediated reactions. In this way, theplatelet release reaction results in increased permeability during immunologic reactions.
See also
References
Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005 Mar 17;352(11):1112-20. PMID: 15784664
Cote F, Fligny C, Fromes Y, Mallet J, Vodjdani G. Recent advances in understanding serotonin regulation of cardiovascular function. Trends Mol Med. 2004 May 1;10(5):232-238. PMID: 15121050
Richter DW, Manzke T, Wilken B, Ponimaskin E. Serotonin receptors: guardians of stable breathing. Trends Mol Med. 2003 Dec;9(12):542-8. PMID: 14659469