Mitosis and meiosis are remarkable processes during which cells undergo profound changes in their structure and physiology. These events are orchestrated with a extreme precision, with different activities being switched on and off at precise times and locations throughout the cell.
One essential ’conductor’ of this symphony is the chromosomal passenger complex (CPC), which comprises Aurora-B protein kinase (AURKA), the inner centromere protein INCENP, survivin (BIRC5) and borealin (CDCA8) (also known as Dasra-B).
See also
chromosome-microtubule interactions
sister chromatid cohesion
cytokinesis
mitosis
meiosis
References
Ruchaud S, Carmena M, Earnshaw WC. Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol. 2007 Oct;8(10):798-812. PMID: 17848966