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Monday 15 September 2003

Process by which the daugther cells separate from each other at the end of the cellular division

Cytokinesis follows nuclear division and generates two distinct daughter cells, each replete with a full complement of the genome and cytoplasmic organelles.

Completion of cell division during cytokinesis requires temporally and spatially regulated communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell membrane.

Exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated proteolysis. Continuous signals from microtubules are required to maintain the position of the cleavage furrow, and these signals control the localization of myosin II independently of other furrow components.


- Otegui MS, Verbrugghe KJ, Skop AR. Midbodies and phragmoplasts: analogous structures involved in cytokinesis. Trends Cell Biol. 2005 Aug;15(8):404-13. PMID: 16009554

- Piekny A, Werner M, Glotzer M. Cytokinesis: welcome to the Rho zone. Trends Cell Biol. 2005 Dec;15(12):651-8. PMID: 16243528

- Wang YL. The mechanism of cortical ingression during early cytokinesis: thinking beyond the contractile ring hypothesis. Trends Cell Biol. 2005 Nov;15(11):581-8. PMID: 16209923

- Reichl EM, Effler JC, Robinson DN. The stress and strain of cytokinesis. Trends Cell Biol. 2005 Apr;15(4):200-6. PMID: 15817376

- Burgess DR, Chang F. Site selection for the cleavage furrow at cytokinesis. Trends Cell Biol. 2005 Mar;15(3):156-62. PMID: 15752979

- McCollum D. Cytokinesis: the central spindle takes center stage. Curr Biol. 2004 Nov 23;14(22):R953-5. PMID: 15556852

- Albertson R, Riggs B, Sullivan W. Membrane traffic: a driving force in cytokinesis. Trends Cell Biol. 2005 Feb;15(2):92-101. PMID: 15695096

- Balasubramanian MK, Bi E, Glotzer M. Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells. Curr Biol. 2004 Sep 21;14(18):R806-18. PMID: 15380095

- Robinson DN, Spudich JA. Mechanics and regulation of cytokinesis. Curr Opin Cell Biol. 2004 Apr;16(2):182-8. PMID: 15196562

- Strickland LI, Burgess DR. Pathways for membrane trafficking during cytokinesis. Trends Cell Biol. 2004 Mar;14(3):115-8. PMID: 15055200

- Adams RR, Carmena M, Earnshaw WC. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 2001 Feb;11(2):49-54. PMID: 11166196

- Robinson DN, Spudich JA. Towards a molecular understanding of cytokinesis. Trends Cell Biol. 2000 Jun;10(6):228-37. PMID: 10802538