bronchopulmonary dysplasia
chronic lung disease of prematurity
Synopsis
acute bronchopulmonary dysplasia
- necrotizing bronchiolitis (bronchiolar necrosis)
- alveolar epithelium necrosis
- persistence of pulmonary hyaline membranes
- extensive acinar damage
- alveolar cell hyperplasia
- alveolar cell regenrative aspects
- septal edema
pulmonary fibroplasia and pulmonary fibrosis
- peribhronchiolar fibroplasia (peribhronchiolar fibrosis)
- alveolar septal fibroplasia (alveolar septal fibrosis)
chronic bronchopulmonary dysplasia
- bulky lungs, firm lungs
- macroscopic irregular fissures (association of hyperexpanded and atelelectatic acini)
- septal fibroplasia and septal fibrosis
- bronchial epithelial metaplasia
- bronchiolar epithelial metaplasia
- bronchiolar smooth muscle hypertrophy (brochiolar smooth muscle hyperplasia)
- marked bronchial secretion
- associations of clusters of hyperexpanded alveoli (dilated alveoli) and emphysematous alveoli with clusters of atelectatic alveoli
Etiology
oxygen toxicity
poor bronchial drainage
mechanical ventilation
Synopsis
pulmonary vascular lesions
pulmonary hypertension
References
Gorenflo M, Vogel M, Obladen M. Pulmonary vascular changes in bronchopulmonary dysplasia: a clinicopathologic correlation in short- and long-term survivors. Pediatr Pathol. 1991 Nov-Dec;11(6):851-66. PMID: 1775401
Tomashefski JF Jr, Oppermann HC, Vawter GF, Reid LM. Bronchopulmonary dysplasia: a morphometric study with emphasis on the pulmonary vasculature. Pediatr Pathol. 1984;2(4):469-87. PMID: 6536000