Human pathology

Home page > D. Systemic pathology > Hematologic disorders > Lymph nodes > atypical lymphadenopathies

atypical lymphadenopathies

Definition: Atypical lymphadenopathies fail to achieve the morphologic criteria of a malignant neoplasm, but exceed the usual concepts of follicular, lymphoid, or sinus histiocytic hyperplasias. Rich cellular proliferations usually composed of prominent histiocytes, or immunoblasts, or both with or without a vascular scaffolding obscure the nodal architecture.

Etiology

- infectious lymphadenitis

  • nodal toxoplasmosis
  • nodal infectious mononucleosis
  • nodal zoster
  • vaccination-induced lymphadenopathies

- dermatopathic lymphadenitis (associated with cutaneous disease)
- anticonvulsant pseudolymphoma

  • hypersensitivity to anticonvulsants (usually phenytoin),

- Chediak-Higashi syndrome
- sinus histiocytosis with massive lymphadenopathy
- giant lymph node hyperplasia
- angioimmunoblastic lymphadenopathy
- nodal Kawasaki disease (mucocutaneous lymph node syndrome)

- nodal histiocytoses

  • acute disseminated histiocytosis

See also

- lymph nodes