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atherosclerosis

Definition: Atherosclerosis is a ’narrowing’ or hardening of the arteries, and is a pathological process that involves the progressive expansion of lesions (plaques) that reduce blood flow in arteries.

References

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- Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005 Apr 21;352(16):1685-95. PMID: 15843671

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- Scott J. Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004 Jun;14(3):271-9. PMID: 15172670

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- Kutuk O, Basaga H. Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med. 2003 Dec;9(12):549-57. PMID: 14659470

- de Nigris F, Lerman A, Ignarro LJ, Williams-Ignarro S, Sica V, Baker AH, Lerman LO, Geng YJ, Napoli C. Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends Mol Med. 2003 Aug;9(8):351-9. PMID: 12928037

- Albertini R, Moratti R, De Luca G. Oxidation of low-density lipoprotein in atherosclerosis from basic biochemistry to clinical studies. Curr Mol Med. 2002 Sep;2(6):579-92. PMID: 12243250

- Duval C, Chinetti G, Trottein F, Fruchart JC, Staels B. The role of PPARs in atherosclerosis. Trends Mol Med. 2002 Sep;8(9):422-30. PMID: 12223313

- Ursini F, Davies KJ, Maiorino M, Parasassi T, Sevanian A. Atherosclerosis: another protein misfolding disease? Trends Mol Med. 2002 Aug;8(8):370-4. PMID: 12127722

- Boerwinkle E, Ellsworth DL, Hallman DM, Biddinger A. Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases. Hum Mol Genet. 1996;5 Spec No:1405-10. PMID: 8875244

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