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antigen processing

The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of several APM components is associated with progression and clinical outcome in cervical carcinoma.

Genetic variation in the genes encoding APM components is known to be associated with risk of occurrence of several malignancies.

References

- Mehta AM, Jordanova ES, van Wezel T, Uh HW, Corver WE, Kwappenberg KM, Verduijn W, Kenter GG, van der Burg SH, Fleuren GJ. Genetic variation of antigen processing machinery components and association with cervical carcinoma. Genes Chromosomes Cancer. 2007 Jun;46(6):577-86. PMID: 17366619

- Boes M, Cuvillier A, Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 2004 Apr;14(4):175-83. PMID: 15066635

- Harding CV. Phagocytic processing of antigens for presentation by MHC molecules. Trends Cell Biol. 1995 Mar;5(3):105-9. PMID: 14732164