antigen processing machinery

The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of several APM components is associated with progression and clinical outcome in cervical carcinoma.

Pathology

Genetic variation in the genes encoding APM components is known to be associated with risk of occurrence of several malignancies.

Genetic variation of the antigen processing machinery (APM) components TAP2, LMP7, and ERAP1 is related to cervical carcinoma risk, although the relation with expression and clinical outcome remains unknown.

The location of the ERAP1-127 SNP in the peptidase M1 domain of the ERAP1 aminopeptidase suggests the possibility of direct functional consequences of variation at this locus.

 cervical peidermoid carcinoma (cervical cancer)

• Genetic variation in APM component genes, particularly ERAP1, is an important contributing factor in cervical carcinogenesis, progressive tumor growth and survival.

References

 Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. Mehta AM, Jordanova ES, Corver WE, van Wezel T, Uh HW, Kenter GG, Jan Fleuren G. Genes Chromosomes Cancer. 2009 May;48(5):410-8. PMID: 19202550

 Mehta AM, Jordanova ES, van Wezel T, Uh HW, Corver WE, Kwappenberg KM, Verduijn W, Kenter GG, van der Burg SH, Fleuren GJ. Genetic variation of antigen processing machinery components and association with cervical carcinoma. Genes Chromosomes Cancer. 2007 Jun;46(6):577-86. PMID: 17366619

 Boes M, Cuvillier A, Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends Cell Biol. 2004 Apr;14(4):175-83. PMID: 15066635

 Harding CV. Phagocytic processing of antigens for presentation by MHC molecules. Trends Cell Biol. 1995 Mar;5(3):105-9. PMID: 14732164