Some neurotrophic factors were originally discovered through their neuronal effects and then later found to also have angiogenic activity (for example, brain-derived neurotrophic factor (BDNF)).
Some were originally discovered through their angiogenic effects and then later found to also have neuroprotective activity (for example, vascular endothelial growth factor (VEGF)).
Others are more pleiotropic but still have relevant neurovascular activities, being involved in both angiogenesis and neuroprotection (for example, transforming growth factor-1 (TGF1) and insulin-like growth factor 1 (IGF1)).
Types
angioneurins discovered through their neuronal effects
- NGF (nerve growth factor)
- BDNF (brain-derived neurotrophic factor)
- NT3 (neurotrophin-3)
- NT4 (neurotrophin-4)
angioneurins discovered as angiogenic factors
others angioneurins