IGF1
MIM.147440 12q22-q24.1
Pathology
Insulin-like growth factor-1 (IGF-1) network is a new important signalling cascade in lung carcinogenesis. (#17055338#)
Autocrine IGF-1/IGF-1R signalling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia. (#20007139#)
See also
IGFs
IGF1R
Reviews
Karamouzis MV, Papavassiliou AG. The IGF-1 network in lung carcinoma therapeutics. Trends Mol Med. 2006 Dec;12(12):595-602. Epub 2006 Oct 19. PMID: #17055338#
Bustin SA, Jenkins PJ. The growth hormone-insulin-like growth factor-I axis and colorectal cancer. Trends Mol Med. 2001 Oct;7(10):447-54. PMID: #11597519#
Okada S, Kopchick JJ. Biological effects of growth hormone and its antagonist. Trends Mol Med. 2001 Mar;7(3):126-32. PMID: #11286784#
Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 2002 Jun;18(6):295-301. PMID: #12044358#
References
Autocrine IGF-1/IGF-1R signalling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody. Chapuis N, Tamburini J, Cornillet-Lefebvre P, Gillot L, Bardet V, Willems L, Park S, Green AS, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. Haematologica. .PMID: #20007139#