Vinculin is a cytoskeletal protein associated with the cytoplasmic face of both cell-cell and cell-extracellular matrix adherens-type junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.
Pathology
germline mutations of VCL in dilated cardiomyopathy (CMD1W) (MIM.611407)
See also
TLNs: TLN1, TLN2
ITGs
VILs: VIL1, VIL2
References
Bailly M. Connecting cell adhesion to the actin polymerization machinery: vinculin as the missing link? Trends Cell Biol. 2003 Apr;13(4):163-5. PMID: 12667752