VASPs
Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton.
Ena/VASP function might control actin dynamics. These proteins are linked to various signaling pathways.
The phenotypes of mouse embryos lacking all members of the Ena/VASP family reveals roles for these molecules in cortical development in brain.
References
Sechi AS, Wehland J. ENA/VASP proteins: multifunctional regulators of actin cytoskeleton dynamics. Front Biosci. 2004 May 1;9:1294-310. PMID: 14977545
Krause M, Dent EW, Bear JE, Loureiro JJ, Gertler FB. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol. 2003;19:541-64. PMID: 14570581
Kwiatkowski AV, Gertler FB, Loureiro JJ. Function and regulation of Ena/VASP proteins. Trends Cell Biol. 2003 Jul;13(7):386-92. PMID: 12837609