TNFRSF9
TNFRSF9 (ILA) is a member of the tumor necrosis factor (TNF) receptor family (TNFSFs). Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiologic processes and play an important role in the regulation of immune responses.
ILA is expressed by activated T and B lymphocytes and monocytes.
In mouse
Mouse 4-1BBL is a 50 kDa, 309 aa residue transmembrane glycoprotein that is the largest of the TNFSF members. With a predicted molecular weight of 34 kDa, the molecule has an 82 aa residue cytoplasmic region, a 21 aa residue transmembrane segment, and a 206 aa residue extracellular domain.
Although human and mouse 4-1BB molecules exhibit 60% identity at the aa level, human and mouse 4-1BBL molecules exhibit only 36% identity at the aa level. This level of cross species conservation is much lower than that shown by other members of the TNFSF.
In mice, two ligands are known for 4-1BB: 4-1BBL and laminin.30 Cells known to express 4-1BBL include B cells, dendritic cells, and macrophages.
See also
