Definition: A self-renewing cell with the potential to give rise to a variety of cells, including progenitor cells.
Subtypes
embryonic stem cells
umbilical cord stem cells
adult stem cells
- cutaneous stem cells
- marrow stem cells
- mesenchymal stem cells
Videos
Characteristics of Stem Cells (Part 1 of 4)
Pluripotent Stem Cells in the Early Embryo (Part 2 of 4)
Stem Cells in the Adult Body (Part 3 of 4)
Stem cells and development
Embryonic Stem Cells in Culture (Part 4 of 4)
References
Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13. PMID: 17717515
Chute JP. Stem cell homing. Curr Opin Hematol. 2006 Nov;13(6):399-406. PMID: 17053451
Kaufmann WK. Dangerous entanglements. Trends Mol Med. 2006 Jun;12(6):235-7. PMID: 16631407
Zhang M, Rosen JM. Stem cells in the etiology and treatment of cancer. Curr Opin Genet Dev. 2006 Feb;16(1):60-4. PMID: 16377171
Eckfeldt CE, Mendenhall EM, Verfaillie CM. The molecular repertoire of the ’almighty’ stem cell. Nat Rev Mol Cell Biol. 2005 Sep;6(9):726-37. PMID: 16103873
Xi R, Kirilly D, Xie T. Molecular mechanisms controlling germline and somatic stem cells: similarities and differences. Curr Opin Genet Dev. 2005 Jun 9; PMID: 15950455
Mayhall EA, Paffett-Lugassy N, Zon LI. The clinical potential of stem cells. Curr Opin Cell Biol. 2004 Dec;16(6):713-20. PMID: 15530786
Zipori D. The nature of stem cells: state rather than entity. Nat Rev Genet. 2004 Nov;5(11):873-8. PMID: 15520797
Sablowski R. Plant and animal stem cells: conceptually similar, molecularly distinct? Trends Cell Biol. 2004 Nov;14(11):605-11. PMID: 15519849
Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 2003 Dec;3(12):895-902. PMID: 14737120
Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5. Epub 2003 Oct 31. PMID: 14595015
Rosenthal N. Prometheus’s vulture and the stem-cell promise.N Engl J Med. 2003 Jul 17;349(3):267-74. PMID: 12867611
Verfaillie CM. Adult stem cells: assessing the case for pluripotency. Trends Cell Biol. 2002 Nov;12(11):502-8. PMID: 12446111
Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 2002 Sep;12(9):432-8. PMID: 12220864
Bjorklund A, Svendsen CN. Chimeric stem cells. Trends Mol Med. 2001 Apr;7(4):144-6. PMID: 11286926
Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol. 2001;17:387-403. PMID: 11687494
Tsai RY, Kittappa R, McKay RD. Plasticity, niches, and the use of stem cells. Dev Cell. 2002 Jun;2(6):707-12. PMID: 12062083
Fuchs E, Segre JA. Stem cells: a new lease on life. Cell. 2000 Jan 7;100(1):143-55. PMID: 10647939
Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell. 2000 Jan 7;100(1):157-68. PMID: 10647940