Pathology
somatic mutation in
- lung carcinoma (15%) (15287030)
- pancreatic carcinomas
- prostatic carcinomas
- mammary carcinomas (breast cancers)
BRG1/BRM expression was found lost in 10% of primary lung tumors correlating with a poor prognostic outcome.
Animal models
Whereas Brg1-deficiency causes early embryonic lethality in mice, Brg1+/- animals are prone to epithelial tumors, possibly due to haploinsufficiency for Brg1 in tumor suppression, as the outgrowing tumors retained the remaining wild-type Brg1 allele. Brm-deficient mice are viable, likely via adaptive upregulation of Brg1.