Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane.
RDX has a significant homology in sequence to VIL2 (ezrin) (MIM.123900), EBP41 (protein 4.1) (MIM.130500), TLN1 (talin)(MIM.186745), MSN and NF2 (merlin) (MIM.607379).
These proteins constitute a family with structural and probably functional relationships; all of them are localized to the submembranous cytoskeleton (See ERM proteins).