Members: AKTs, PTEN
Pathology (Dysregulation of the phosphoinositol-3-kinase/Akt pathway)
PTEN germline mutations and dysregulation of the phosphoinositol-3-kinase/Akt pathway
- Cowden disease
- Bannayan-Riley-Ruvalcaba syndrome
- Lhermitte-Duclos disease
genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3’-kinase/protein kinase B (Akt) signal transduction pathway in glioblastoma (14655756)
ERBB3 mutations in lethal congenital contractural syndrome type 2 (LCCS2) (17701904)
- ERBB3 (Her3) is an activator of the phosphatidylinositol-3-kinase/Akt pathway, regulating cell survival and vesicle trafficking. ERBB3 is essential for the generation of precursors of Schwann cells that normally accompany peripheral axons of motor neurons.
Se also
TSC/mTOR pathway
Reviews
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. PMID: 16341064
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature. 2005 Aug 11;436(7052):792. PMID: 16094359
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan;37(1):19-24. PMID: 15624019
Abraham RT. PI 3-kinase related kinases: ’big’ players in stress-induced signaling pathways. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):883-7. PMID: 15279773
Brader S, Eccles SA. Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. Tumori. 2004 Jan-Feb;90(1):2-8. PMID: 15143962
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002 Jul;2(7):489-501. PMID: 12094235
Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002 May 31;296(5573):1655-7. PMID: 12040186
Testa, J. R.; Bellacosa, A. AKT plays a central role in tumorigenesis. Proc. Nat. Acad. Sci. 98: 10983-10985, 2001. 11572954
Weaver SA, Ward SG. Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer? Trends Mol Med. 2001 Oct;7(10):455-62. PMID: 11597520
References
Knobbe CB, Reifenberger G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3’-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 2003 Oct;13(4):507-18. PMID: 14655756