Niban
The Niban/NIBAN gene is specifically expressed in hereditary renal carcinomas of model animals and in human malignancies, including renal cancers.
Although the expression profiles of Niban/NIBAN suggest that it plays an important role in carcinogenesis, no functional information has yet been reported.
Niban is involved in the ER stress response and Niban can modulate cell death signaling by regulating translation. (17588536)
The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation. (17588536)
Pathology
Niban is a recently identified molecular marker of renal carcinogenesis in the Tsc2 gene-mutant Eker rat. Niban expression is most dramatically increased in the early stage of renal carcinogenesis and might decline during malignant progression. Niban is also expressed in various histologic types of human renal cell carcinoma. Therefore, Niban might be a good marker for renal carcinogenesis in both animal models and humans.
Niban is expressed in subsets of thyroid tumors and Hashimoto?s thyroiditis. (16949643)
References
Sun GD, Kobayashi T, Abe M, Tada N, Adachi H, Shiota A, Totsuka Y, Hino O. The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation. Biochem Biophys Res Commun. 2007 Aug 17;360(1):181-7. PMID: 17588536
Matsumoto F, Fujii H, Abe M, Kajino K, Kobayashi T, Matsumoto T, Ikeda K, Hino O. A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto?s thyroiditis. Hum Pathol. 2006 Dec;37(12):1592-600. PMID: 16949643
Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M. Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. Hum Pathol. 2005 Apr;36(4):341-7. PMID: 15891994
Hino O. Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model. Curr Mol Med. 2004 Dec;4(8):807-11. PMID: 15579027
Adachi H, Majima S, Kon S, Kobayashi T, Kajino K, Mitani H, Hirayama Y, Shiina H, Igawa M, Hino O. Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. Oncogene. 2004 Apr 22;23(19):3495-500. PMID: 14990989
Majima S, Kajino K, Fukuda T, Otsuka F, Hino O.A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.Jpn J Cancer Res. 2000 Sep;91(9):869-74. PMID: 11011112