cMYC is a transcription factor. MYC at 8q24.
Pathology
deregulation in B-cell lymphomas
- Burkitt lymphoma
- Burkitt-like lymphoma
- diffuse large B-cell ymphoma (DLBCLs) (15%)
cMYC rearrangements have no clear effect on survival.
Cytogenetics
t(8;14) which brings the cMYC gene on 8q24 under the control of the IGH promoter
HIF-MYC interactions
The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia).
Many tumours contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumour cells, which tend to exist in a hypoxic microenvironment.
References
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Abramson JS, Shipp MA. Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood. 2005 Aug 15;106(4):1164-74. PMID: 15855278
Shachaf CM, Felsher DW. Rehabilitation of cancer through oncogene inactivation. Trends Mol Med. 2005 Jul;11(7):316-21. PMID: 15955741
Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB. Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer. 2004 Jul;4(7):562-8. PMID: 15229481
Secombe J, Pierce SB, Eisenman RN. Myc: a weapon of mass destruction. Cell. 2004 Apr 16;117(2):153-6. PMID: 15084254
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Wanzel M, Herold S, Eilers M. Transcriptional repression by Myc. Trends Cell Biol. 2003 Mar;13(3):146-50. PMID: 12628347
Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer. 2002 Oct;2(10):764-76. PMID: 12360279
Zhou ZQ, Hurlin PJ. The interplay between Mad and Myc in proliferation and differentiation. Trends Cell Biol. 2001 Nov;11(11):S10-4. PMID: 11684436