KIT
MIM.164920
c-kit, mast cell growth factor, MCGF, stem cell factor receptor, SCFR, CD117
Expression in tumors (Exemples)
chromophobe renal cell carcinoma (100%)
renal oncocytoma (100%)
Pathology
KIT activating mutations in
- gastrointestinal stromal tumor (GIST)
- mastocytosis
- testicular germ-cell tumors (TGCT)
Use in diagnosis
Differential diagnosis between chromophobe renal cell carcinoma and the granular variant of clear cell renal cell carcinoma (15832088)
References
Wang HY, Mills SE. KIT and RCC Are Useful in Distinguishing Chromophobe Renal Cell Carcinoma From the Granular Variant of Clear Cell Renal Cell Carcinoma. Am J Surg Pathol. 2005 May;29(5):640-646. PMID: 15832088