Pathology
overexpression in tumors
- Wilms tumor (nephroblastoma)
- hepatoblastoma
- pancreatoblastoma
Expression levels of the ret proto-oncogene (RET), insulin-like growth factor 1 receptor (IGFR1), and insulin-like growth factor 2 (IFG2) correlate with poor metastasis-free survival, supporting a role for ERK/MAPK and PI3K/AKT pathways in clinically aggressive myxoid liposarcomas. (19368956)
See also
IGF2
References
Chao W, D’Amore PA. IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev. 2008 Apr;19(2):111-20. PMID: 18308616
Arney KL. H19 and Igf2—enhancing the confusion ? Trends Genet. 2003 Jan ;19(1):17-23. PMID : 12493244