G-protein diseases
Pathology (G protein diseases)
A. Defective signal termination - signal excessive
cholera
adenoma of the pituitary (G-s-alpha)
adenoma of the thyroid (G-s-alpha)
adenoma of the adrenals (G-i2-alpha)
adenoma of the ovary (G-i2-alpha)
McCune-Albright syndrome (G-s-alpha)
B. Absent or inactive G-alpha - signal deficient
pseudohypoparathyroidism type Ia (G-s-alpha)
pseudohypoparathyroidism type Ib (G-s-alpha)
night blindness (G-t-alpha)
C. Abnormal signal initiation - inadequate or excessive signal
pertussis (G-i-alpha)
pseudo hypoparathyroidism type Ia (G-s-alpha)
testotoxicosis with pseudohypoparathyroidism type Ia (G-s-alpha)
essential hypertension (beta3)
References
Farfel Z, Bourne HR, Iiri T. The expanding spectrum of G protein diseases. N Engl J Med. 1999 Apr 1;340(13):1012-20. PMID: 10099144