Archipelago is an F-box protein with 7 tandem WD (tryptophan-aspartic acid) repeats. It binds directly to cyclin E1 (CCNE1) and is thought to target it for ubiquitin-mediated degradation.
FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase.
SCF(FBW7) degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN.
FBW7 is also a tumour suppressor, the regulatory network of which is perturbed in many human malignancies.
Numerous cancer-associated mutations in FBW7 and its substrates have been identified, and loss of FBW7 function causes chromosomal instability and tumorigenesis.
References
Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer. 2007 Dec 20; PMID: 18094723
Rajagopalan H, Lengauer C. hCDC4 and genetic instability in cancer. Cell Cycle. 2004 Jun;3(6):693-4. PMID: 15118416
Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C. Inactivation of hCDC4 can cause chromosomal instability. Nature. 2004 Mar 4;428(6978):77-81. PMID: 14999283