ubiquitin

Function

 Ubiquitin modifications target proteins to the 26S proteasome for proteolysis.
 polyubiquitin (polyUb) chains promote proteasomal degradation
 monoubiquitin (monoUb) play a role in vesicular trafficking

Types

 polyubiquitin (polyUb)
 monoubiquitin (monoUb)

Pathology of ubiquitin

 ubiquitin-positive deposits found in patients with Alzheimer’s disease (AD)

See also

 ubiquitin-positive deposits

References¸

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 Huang TT, D’Andrea AD. Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol. 2006 May;7(5):323-34. PMID: 16633336

 Sun L, Chen ZJ. The novel functions of ubiquitination in signaling. Curr Opin Cell Biol. 2004 Apr;16(2):119-26. PMID: 15196553

 Ohta T, Fukuda M. Ubiquitin and breast cancer. Oncogene. 2004 Mar 15;23(11):2079-88. PMID: 15021895

 Hegde AN, DiAntonio A. Ubiquitin and the synapse. Nat Rev Neurosci. 2002 Nov;3(11):854-61. PMID: 12415293

 Buchberger A. From UBA to UBX: new words in the ubiquitin vocabulary. Trends Cell Biol. 2002 May;12(5):216-21. PMID: 12062168

 Hicke L. Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol. 2001 Mar;2(3):195-201. PMID: 11265249

 Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 2000 Oct;10(10):429-39. PMID: 10998601

 Jentsch S, Pyrowolakis G. Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 2000 Aug;10(8):335-42. PMID: 10884686

 Lowe J, Mayer RJ, Landon M. Ubiquitin in neurodegenerative diseases. Brain Pathol. 1993 Jan;3(1):55-65. PMID: 8269084

 Mayer RJ, Lowe J, Lennox G, Doherty F, Landon M. Intermediate filaments and ubiquitin: a new thread in the understanding of chronic neurodegenerative diseases. Prog Clin Biol Res. 1989;317:809-18. PMID: 2557642

 Ohta M, Marceau N, Perry G, Manetto V, Gambetti P, Autilio-Gambetti L, Metuzals J, Kawahara H, Cadrin M, French SW. Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Lab Invest. 1988 Dec;59(6):848-56. PMID: 2462130