MCFD2, as LMAN1, is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). MCFD2 is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1.
References
Olkkonen VM, Ikonen E. Genetic defects of intracellular-membrane transport. N Engl J Med. 2000 Oct 12;343(15):1095-104. PMID: 11027745